References

PRP for Aesthetic use:

1.          Puri N. Platelet rich plasma in dermatology and aesthetic medicine. Our Dermatology Online [Internet]. 2015;6(2):207–11. Available from: http://www.odermatol.com/issue-in-html/2015-2-24/

2.          Díaz-Ley B, Cuevast J, Alonso-Castro L, Calvo MI, Ríos-Buceta L, Orive G, et al. Benefits of plasma rich in growth factors (PRGF) in skin photodamage: Clinical response and histological assessment. Dermatol Ther. 2015;28(4):258–63. https://www.ncbi.nlm.nih.gov/pubmed/25864463

3.          Oyunsaikhan S, Amarsaikhan B, Batbayar B, Erdenetsogt D. Morphometric study of facial wrinkles and aesthetic skin as dermaroller treatment combined with platelet rich plasma (PRP). 2017;3:238–2364. Available from: http://dx.doi.org/10.17629/www.diagnosticpathology.eu-2017-3:238

https://www.researchgate.net/publication/319077997_Morphometric_study_of_facial_wrinkles_and_aesthetic_skin_as_dermaroller_treatment_combined_with_platelet_rich_plasma_PRP

4.          Kim H, Gallo J. Evaluation of the effect of platelet-rich plasma on recovery after ablative fractional photothermolysis. JAMA Facial Plast Surg. 2015;17(2):97–102. https://www.ncbi.nlm.nih.gov/pubmed/25429396

5.          Redaelli A, Romano D, Marcianó A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol. 2010;9(5):466–72.

http://www.bo-medical.com/sites/bo-medical.com/files/injectables/Face%20and%20neck%20revitalization%20with%20PRP.pdf

6.          Elghblawi E. Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering. J Cosmet Dermatol. 2018;17(3):423–30. https://www.ncbi.nlm.nih.gov/pubmed/28887865

7.          Ibrahim MK, Ibrahim SM, Salem AM. Skin microneedling plus platelet-rich plasma versus skin microneedling alone in the treatment of atrophic post acne scars: a split face comparative study. J Dermatolog Treat [Internet]. 2018;29(3):281–6. Available from: http://dx.doi.org/10.1080/09546634.2017.1365111

8.          Bulam H, Ayhan S, Sezgin B, Zinnuroglu M, Konac E, Varol N, et al. The Inhibitory Effect of Platelet-Rich Plasma on Botulinum Toxin Type-A: An Experimental Study in Rabbits. Aesthetic Plast Surg. 2015;39(1):134–40. https://www.ncbi.nlm.nih.gov/pubmed/25413010

PRP for Sexual Health:

1.          Matz EL, Pearlman AM, Terlecki RP. Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions. Investig Clin Urol [Internet]. 2018 Jan [cited 2018 Oct 8];59(1):61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29333517

2.          Kim SH, Park ES, Kim TH. Rejuvenation Using Platelet-rich Plasma and Lipofilling for Vaginal Atrophy and Lichen Sclerosus. J Menopausal Med [Internet]. 2017 Apr [cited 2018 Oct 8];23(1):63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28523261

3.          Virag R, Sussman H, Lambion S, de Fourmestraux V. Evaluation of the benefit of using a combination of autologous platelet rich-plasma and hyaluronic acid for the treatment of Peyronie’s disease. Sex Heal Issues [Internet]. 2017;1(1):1–8. Available from: http://www.oatext.com/evaluation-of-the-benefit-of-using-a-combination-of-autologous-platelet-rich-plasma-and-hyaluronic-acid-for-the-treatment-of-Peyronies-disease.php

4.          Virag R, Sussman H. PS-05-007 Plasma rich platelets and hyaluronic acid improves peyronie’s disease: A case control study of 75 cases. J Sex Med [Internet]. 2017;14(4):e121. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1743609517302345

5.          Biguria R, Ziegler OR, Farias DA. Advances in Plastic & Reconstructive Surgery Research Article ISSN : 2572-6684 Combining Hyaluronic Acid with Autologous Platelet Rich Plasma ( APRP ) for the Treatment of Female Sexual Dysfunction and Desire . 2017;136–9. https://applispublishers.com/wp-content/uploads/2016/07/APRS-01-000137.pdf

6.          Hamori CA, Banwell PE, Alinsod R, editors. Chapter 15 O-Shot®. In: Female Cosmetic Genital Surgery [Internet]. Stuttgart: Georg Thieme Verlag; 2017 [cited 2018 Oct 8]. Available from: http://www.thieme-connect.de/products/ebooks/lookinside/10.1055/b-0037-144702

7.          Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med. 2015;8(1):1286–90. https://www.ncbi.nlm.nih.gov/pubmed/25785127

8.          Runels C, Melnick H, Debourbon E R. A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the Treatment of Female Sexual Dysfunction. J Women’s Heal Care. 2014;3:169. https://www.omicsonline.org/open-access/a-pilot-study-of-the-effect-of-localized-injections-of-autologous-platelet-rich-plasma-prp-for-the-treatment-of-female-sexual-dysfunction-2167-0420.1000169.php?aid=27349

9.          Runels BC. Activate the Female Orgasm System. https://www.amazon.com/Activate-Female-Orgasm-System-Shot%C2%AE/dp/1494778203

PRP for Hair rejuvenation

1.          Surgery R, Heart S. Tissue Engineering and Regenerative Medicine T ISSUE E NGINEERING AND R EGENERATIVE M EDICINE The Effect of Platelet-Rich Plasma in Hair Regrowth : A Randomized Placebo-Controlled Trial. 2015;1317–23. https://www.ncbi.nlm.nih.gov/pubmed/26400925

2.          Gkini M-A, Kouskoukis A-E, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg [Internet]. 2014;7(4):213. Available from: http://www.jcasonline.com/text.asp?2014/7/4/213/150743

3.          Gentile P. The Effect of Platelet-Rich Plasma in Hair Regrowth. Stem Cells Transl Med. 2014;4:1344–51. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622412/

4.          Hair rejuvenation with PRP | PRIME Journal [Internet]. [cited 2018 Oct 8]. Available from: https://www.prime-journal.com/hair-rejuvenation-with-prp/

Basic Science of PRP

1.          Park H-B, Yang J-H, Chung K-H. Characterization of the cytokine profile of platelet rich plasma (PRP) and PRP-induced cell proliferation and migration: Upregulation of matrix metalloproteinase-1 and -9 in HaCaT cells. Korean J Hematol [Internet]. 2011;46(4):265. Available from: https://synapse.koreamed.org/DOIx.php?id=10.5045/kjh.2011.46.4.265

2.          Xian LJ, Roy Chowdhury S, Bin Saim A, Bt Hj Idrus R. Concentration-dependent effect of platelet-rich plasma on keratinocyte and fibroblast wound healing. Cytotherapy [Internet]. 2015;17(3):293–300. Available from: http://dx.doi.org/10.1016/j.jcyt.2014.10.005

3.          Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. …  Surgery, Oral Med  … [Internet]. 1998;85(6):638–46. Available from: http://www.sciencedirect.com/science/article/pii/S1079210498900294%5Cnhttp://www.ncbi.nlm.nih.gov/pubmed/9638695

4.          Marx RE. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP? Implat Dent. 2001;10(4):225–8. https://www.ncbi.nlm.nih.gov/pubmed/11813662

5.          Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158–67. https://www.ncbi.nlm.nih.gov/pubmed/19187989

6.          Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbé G, Del Corso M, Inchingolo F, et al. 15-Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol [Internet]. 2012;13(7):1145–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21740377

7.          Slapnicka J, Fassmann A, Strasak L, Augustin P, Vanek J. Effects of Activated and Nonactivated Platelet-Rich Plasma on Proliferation of Human Osteoblasts In Vitro. J Oral Maxillofac Surg. 2008;66(2):297–301. https://www.ncbi.nlm.nih.gov/pubmed/18201612

8.          Ringkamp M, Schmelz M, Kress M, Allwang M, Ogilvie A, Reeh PW. Activated human platelets in plasma excite nociceptors in rat skin, in vitro. Neurosci Lett. 1994;170(1):103–6. https://www.ncbi.nlm.nih.gov/pubmed/8041482

9.          Zhevago NA, Samoilova KA. Pro- and anti-inflammatory cytokine content in human peripheral blood after its transcutaneous (in vivo) and direct (in vitro) irradiation with polychromatic visible and infrared light. Photomed Laser Surg [Internet]. 2006;24(2):129–39. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16706691

10.        Bendinelli P, Matteucci E, Dogliotti G, Corsi MM, Banfi G, Maroni P, et al. Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: Mechanisms of NF-κB inhibition via HGF. J Cell Physiol. 2010;225(3):757–66. https://www.ncbi.nlm.nih.gov/pubmed/20568106

11.        Lee Y, Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, et al. Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth. Dermatologic Surg. 2012;38(7 PART 1):1040–6. https://www.ncbi.nlm.nih.gov/pubmed/22455565

12.        Davì G, Patrono C. Platelet Activation and Atherothrombosis. N Engl J Med [Internet]. 2007;357(24):2482–94. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMra071014

13.        Cavallo C, Roffi A, Grigolo B, Mariani E, Pratelli L, Merli G, et al. Platelet-Rich Plasma: The Choice of Activation Method Affects the Release of Bioactive Molecules. Biomed Res Int. 2016;2016. https://www.ncbi.nlm.nih.gov/pubmed/27672658

Basic Science of PRP

1.          Park H-B, Yang J-H, Chung K-H. Characterization of the cytokine profile of platelet rich plasma (PRP) and PRP-induced cell proliferation and migration: Upregulation of matrix metalloproteinase-1 and -9 in HaCaT cells. Korean J Hematol [Internet]. 2011;46(4):265. Available from: https://synapse.koreamed.org/DOIx.php?id=10.5045/kjh.2011.46.4.265

2.          Xian LJ, Roy Chowdhury S, Bin Saim A, Bt Hj Idrus R. Concentration-dependent effect of platelet-rich plasma on keratinocyte and fibroblast wound healing. Cytotherapy [Internet]. 2015;17(3):293–300. Available from: http://dx.doi.org/10.1016/j.jcyt.2014.10.005

3.          Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. …  Surgery, Oral Med  … [Internet]. 1998;85(6):638–46. Available from: http://www.sciencedirect.com/science/article/pii/S1079210498900294%5Cnhttp://www.ncbi.nlm.nih.gov/pubmed/9638695

4.          Marx RE. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP? Implat Dent. 2001;10(4):225–8. https://www.ncbi.nlm.nih.gov/pubmed/11813662

5.          Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158–67. https://www.ncbi.nlm.nih.gov/pubmed/19187989

6.          Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbé G, Del Corso M, Inchingolo F, et al. 15-Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol [Internet]. 2012;13(7):1145–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21740377

7.          Slapnicka J, Fassmann A, Strasak L, Augustin P, Vanek J. Effects of Activated and Nonactivated Platelet-Rich Plasma on Proliferation of Human Osteoblasts In Vitro. J Oral Maxillofac Surg. 2008;66(2):297–301. https://www.ncbi.nlm.nih.gov/pubmed/18201612

8.          Ringkamp M, Schmelz M, Kress M, Allwang M, Ogilvie A, Reeh PW. Activated human platelets in plasma excite nociceptors in rat skin, in vitro. Neurosci Lett. 1994;170(1):103–6. https://www.ncbi.nlm.nih.gov/pubmed/8041482

9.          Zhevago NA, Samoilova KA. Pro- and anti-inflammatory cytokine content in human peripheral blood after its transcutaneous (in vivo) and direct (in vitro) irradiation with polychromatic visible and infrared light. Photomed Laser Surg [Internet]. 2006;24(2):129–39. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16706691

10.        Bendinelli P, Matteucci E, Dogliotti G, Corsi MM, Banfi G, Maroni P, et al. Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: Mechanisms of NF-κB inhibition via HGF. J Cell Physiol. 2010;225(3):757–66. https://www.ncbi.nlm.nih.gov/pubmed/20568106

11.        Lee Y, Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, et al. Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth. Dermatologic Surg. 2012;38(7 PART 1):1040–6. https://www.ncbi.nlm.nih.gov/pubmed/22455565

12.        Davì G, Patrono C. Platelet Activation and Atherothrombosis. N Engl J Med [Internet]. 2007;357(24):2482–94. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMra071014

13.        Cavallo C, Roffi A, Grigolo B, Mariani E, Pratelli L, Merli G, et al. Platelet-Rich Plasma: The Choice of Activation Method Affects the Release of Bioactive Molecules. Biomed Res Int. 2016;2016. https://www.ncbi.nlm.nih.gov/pubmed/27672658

PRP for Sports and Tissue related Injuries

1.          Gill PSPS. A Randomized Controlled Study to Evaluate the Effectiveness of Local Platelet Rich Plasma ( PRP ) Injection for the Management of the Cases of Planter Fasciitis - Final Outcome of 179 Cases at 12 Months. Indian J Appl Res. 2016;6(November):59–64.

2.          Kajetanek C, Thaunat M, Guimaraes T, Carnesecchi O, Daggett M, Sonnery-Cottet B. Arthroscopic treatment of painful Sinding-Larsen-Johansson syndrome in a professional handball player. Orthop Traumatol Surg Res [Internet]. 2016;102(5):677–80. Available from: http://dx.doi.org/10.1016/j.otsr.2016.05.011

3.          Mishra A, Gosens T. Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Elbow. Oper Tech Sports Med [Internet]. 2011;19(3):170–6. Available from: http://dx.doi.org/10.1053/j.otsm.2011.03.003

4.          Mishra AK, Skrepnik N V., Edwards SG, Jones GL, Sampson S, Vermillion DA, et al. Efficacy of platelet-rich plasma for chronic tennis elbow: A double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Am J Sports Med. 2014;42(2):463–71.

5.          Laudy ABM, Bakker EWP, Rekers M, Moen MH. Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: A systematic review and meta-analysis. Br J Sports Med. 2015;49(10):657–72.

6.          Fiorentino S, Kon E, Filardo G. European De fi nitions , Current Use , and EMA Stance of Platelet-Rich Plasma in Sports Medicine. 2015;1(212).

7.          Hamilton B, Tol JL, Knez W, Chalabi H. Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): Overlooked biochemical factors that could influence PRP treatment. Br J Sports Med. 2015;49(14):957–60.

8.          Cole BJ, Fortier LA, Karas V, Hussey KE, Tilton AK, Merkow DB, et al. Hyaluronic acid versus platelet-rich plasma: Double-blind randomized controlled trial comparing clinical outcomes and intra-articular biology for treatment of knee arthritis. Orthop J Sport Med. 2015;3(7):2015.

9.          Hanci M, Karamese M, Tosun Z, Aktan TM, Duman S, Savaci N. Intra-Articular platelet-rich plasma injection for the treatment of temporomandibular disorders and a comparison with arthrocentesis. J Cranio-Maxillofacial Surg. 2015;43(1):162–6.

10.        Jiang S, Yan H, Fan D, Song J, Fan C. Multi-layer electrospun membrane mimicking tendon sheath for prevention of tendon adhesions. Int J Mol Sci. 2015;16(4):6932–44.

11.        Danneberg DJ. Successful treatment of osgood-schlatter disease with autologous-conditioned plasma in two patients. Joints. 2017;5(3):191–3.

12.        Hoskins J, Elliott S. JMU Scholarly Commons Platelet Rich Plasma vs. Corticosteroid Injections in Treatment of Tendinopathies Platelet Rich Plasma vs. Corticosteroid Injections in the Treatment of Tendinopathies James Madison University Physician Assistant Program. 2016; Available from: http://commons.lib.jmu.edu/pacapstones%5Cnhttp://commons.lib.jmu.edu/pacapstones/2/.

13.        Di Matteo B, Filardo G, Kon E, Marcacci M. Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review. Musculoskelet Surg. 2015;99(1).

PRP - Clinical studies for scar reduction.

PRP can be used for the management of various types of scars, including acne scarring and stretch marks. An article published by S Chawla in Journal of Cutaneous and Aesthetic Surgery, demonstrated that “microneedling combined with PRP proved to be good in treating boxcar and rolling scars but had limited efficacy in dealing with ice pick scars.”

In another study, Zhu et al., combined PRP with erbium fractional laser for the management of facial acne or acne scars. The authors noted “PRP combined with erbium fractional laser therapy is an effective and safe approach for treating acne scars or acne, with minimal side-effects, and it simultaneously enhanced the recovery of laser-damaged skin.”

For the management of stretch marks both Suh et al., and Kim et al., demonstrated that PRP, in combination with radiofrequency, is an effective treatment for the management of stretch marks.

 

References:

 

  1. Gumede, P. How PRP can fix damage caused to ethnic hair. A2 Aesthetic and Anti-Ageing Magazine. 2018;27:42-43.

   2. Chawla, S. Split Face Comparative Study of Microneedling with PRP Versus Microneedling with Vitamin C in Treating Atrophic Post           Acne Scars. Journal of cutaneous and aesthetic surgery. 2014;7(4):209-212.

   3. Zhu, J-T, et al. The efficacy of autologous platelet-rich plasma combined with erbium fractional laser therapy for facial acne scars or         acne. Molecular Medicine Reports. 2013;8(1):233-237.

   4. Suh, D-H et al. Treatment of Striae Distensae Combined Enhanced Penetration Platelet-Rich Plasma and Ultrasound after Plasma             Fractional Radiofrequency. Journal of Cosmetic and Laser Therapy Treatment. 2012; 10.3109/14764172.2012.738916

  5.Kim, I et al. Efficacy of intradermal radiofrequency combined with autologous platelet-rich plasma in striae distensae: a pilot study.           International journal of dermatology. 2012; 10.1111/j.1365-4632.2012.05530.x